Emergency services rushed to the scene after the black Lincoln Town Car mowed people down in lower Manhattan.
Cops have said the car was involved in at least two crashes before coming to a stop near Liberty Street and Broadway. The driver of the vehicle has been arrested, and four of the five injured were taken to hospital.
An NYPD spokesman said the car crashed before attempting to flee the scene. It then hit another vehicle and veered onto the pavement, knocking down pedestrians.
Pictures from the scene show the front of black sedan completely smashed in.
Police and firefighters cordoned off the area as they dealt with the major incident.
Detectives said investigations are in their “preliminary” stage.
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Images from the scene show a bicycle crushed next to the crashed car – which occurred less than half a mile from the World Trade Center.
It is also less than a mile from where a suspected terrorist drove a UHaul down a bike track – killing 6.
The five victims are not believed to have life threatening injuries.